Magic Mushrooms as an Alternative to Prozac: A Comprehensive Guide

Have you ever thought psychedelics like magic mushrooms could replace an ineffective antidepressant? You might be desperate to find the proper treatment and care if you are a patient who has tried different treatments.
But, the good news is that scientists recently rediscovered an old method that has been used for hundreds of years and is now the subject of more medical research.
So far, new studies from reliable researchers have shown that magic mushrooms can help with depression, and their effects are not as strong or dangerous as Prozac’s. That information and study evidence will help you through this guide.
Prozac and Shrooms: Which is More Effective?
Magic mushrooms, which contain Psilocybin, make people feel high. On the other hand, Prozac is the brand for the fluoxetine drug, a selective serotonin reuptake inhibitor (SSRI) for depression.
Both magic mushrooms and Prozac induce plasticity to replace lost and deformed synapses in the brain. Although brain plasticity, or shape ability, is a natural process, similar to serotonin production, some adverse events induce brain plasticity but take the form of trauma. As a result, the wiring needs recalibration to bring it back to normal.
Both can also boost serotonin levels in the brain in different ways. Psilocybin alters the number of neurotransmitters in the brain. Prozac, on the other hand, works by increasing serotonin levels and preventing the brain from reabsorbing it.
Which one sounds better to you? Rewiring receptors seems more like Psilocybin, while Prozac is more about how much is in each wire.
Comparison of Magic Mushrooms And Prozac Side Effects
Regarding side effects, magic mushrooms can induce hallucinations and changes in perception of time, mood, and behavior. On the other hand, Prozac can cause side effects such as nausea, insomnia, and sexual dysfunction.
How Else Can Magic Mushrooms Help You?

Psilocybin has many benefits in two critical areas related to your health and well-being.
Medical Uses of Magic Mushrooms
Psilocybin mushrooms, also known as “magic mushrooms,” have been used as medicine for hundreds of years. In the past few years, scientists have looked into using Psilocybin to treat:
- Depression
- Anxiety
- PTSD
- OCD
- Other mental health conditions
- Cancer
- Addiction or Abuse
- Creative Block
- Cluster Headaches
- Fatigue
- Memory Loss
- Stress Relief
- Lack of Emotions
Present studies show that Psilocybin can reduce the symptoms of these conditions and even cause them to go away for good. But magic mushrooms are illegal in many places, and it still needs more research to determine if they are safe and effective for the said issues.
Recreational Uses of Magic Mushrooms
Taking Psilocybin-containing mushrooms for fun to feel their psychedelic effects is called the “recreational use of magic mushrooms.” Some of the possible side effects are:
- Fun or relaxing hallucinations
- Mystical experiences
- Positive changes in how you see, feel, and think.
Can I Attend Shroom and Prozac Synthesis?

Here are some other drugs and antidepressants and whether you can take them with magic mushrooms.
Can You Take Psilocybin While On Antidepressants?
Suppose you are already taking antidepressants and want to try psychedelics. In that case, you should talk to your doctor about any possible risks and ensure it is safe to use psychedelics while taking antidepressants. So far, the only way to be sure is to use one at a time and not both simultaneously.
Can You Take Shrooms On An SSRI?
It would be best not to take Psilocybin with SSRIs since it can cause interactions, particularly serotonin syndrome. SSRIs change serotonin levels in the brain, and psychedelics may raise them.
Although SSRI changes serotonin levels, some of it may not be able to alleviate depression. Psychedelics, on the other hand, are more effective in healing depression. Still, take them separately to avoid any complications.
Can You Take Shrooms On An SNRI?
You can’t take SNRI and Psilocybin shrooms together without a doctor’s advice, just like SSRI. Just ensure only to take shrooms at a time so you can see how they affect your body.
Can You Take Shrooms On A MAOI?
MAOIs stop an enzyme called monoamine oxidase from breaking down neurotransmitters. As mentioned, Psilocybin changes and grows neurotransmitters, so taking it with an MAOI is dangerous.
Can You Take Shrooms On A TCA/TeCA?
Tricyclic antidepressants (TCAs) and tetracyclic antidepressants (TeCAs) treat depression, anxiety, OCD, or long-term pain. There isn’t enough research on the safety and effectiveness of mixing TCAs or TeCAs with Psilocybin, so take each on their own.
Can You Take Shrooms On An NRI/NDRI?

NRIs and NDRI treat ADHD and narcolepsy because they have psychostimulant effects, and they can stop obesity because they reduce appetite. Taking it with magic mushrooms is not advisable because it still needs research, and it would be best to take each separately.
Can You Take Shrooms On An SMS/SARI?
Since Psilocybin is illegal in some states, using illicit drugs would be against the rules of an SMS or Serotonin antagonist and reuptake inhibitors (SARI) program. So, eating magic mushrooms while participating in an SMS or SARI program is not a good idea.
Can You Take Shrooms On Lithium?
Lithium can lessen the intensity of manic episodes, which may or may not be the opposite of what Psilocybin does. So, if you take both simultaneously, it’s more likely that neither will help much.
What About Other Substances?
The drugs and dose you choose should base on reputable medical sources. Some medicines may not be safe or suitable for your health or medical condition.
If you take some of these drugs and none seem to help, you might find that psychedelics work better. Always start with a small amount and try it out independently to determine how it affects you. Combination at the first try and without a doctor’s advice is a clear risk.
What Can I Take Best With Magic Mushroom?
One study by Johns Hopkins Medicine, which opened the most prominent and first Center for Psychedelic and Consciousness Research in the U.S., found that talk therapy works best with Psilocybin to help people with clinical depression. Since Psilocybin makes the brain’s wiring more shapeable, talk therapy directs the wiring to take the correct shape and path.
As a result, some participants in the study who took two doses of the compound felt better and had better thoughts for a year than those who took antidepressants.
Battling Mental Health: Choose What Suits You Best
It would be best if you chose what suits your condition. Not everyone can use medical intervention to treat depression and related mental illnesses.
Getting yourself involved with the psilocybin experience both for medical and recreational activities is one way to save yourself from the debilitating effects of depression and disorders effectively.