Health & Benefits

Psilocin & Serotonin Receptors in the Brain

There are seven classifications of serotonin receptors, each having their subtypes. These receptors are abundant in the central and peripheral nervous systems and the cerebral cortex of the brain. One major group is 5-HT2A receptors. Serotonin is a neurotransmitter that activates these receptors to modulate glutamate, dopamine, epinephrine, and acetylcholine. These receptors affect several biological and neurological processes. They modulate anxiety, cognition, memory, mood, nausea, appetite, and sleep. 


When psilocybin enters the brain, it breaks down into psilocin. Psilocin is the active substance found in magic mushrooms. It reacts to brain receptors, serotonin to induce psychedelic effects. Once the serotonin amount increases, hallucinations take effect. Psilocin expands the consciousness of a person who ingests psilocybin. Researches have shown that psilocybin binds to the 5-HT2A serotonin receptor because it can have the same effects as 5-HT. 

What happens in the brain?

A hand holding magic mushrooms.While research shows that magic mushrooms are now gaining the attention of therapists and medical experts, it is necessary to understand how psilocin works.

After psilocybin breaks into psilocin, this substance makes its way to the brain. 

From the moment it reaches the brain, it prevents the reabsorption of serotonin. Because of their similar structure, it stimulates the receptors in the brain and therefore causes hallucination even with a pseudo stimulus.

The sensory perceptions coming from these receptors make the user feel like the trip takes effect for an extended period than the entire 3-8 hours span of experiencing highness. 

The brain rearranges itself by making mushroom users have a new stable condition once they get the trip. Also, emotional regions of the brain are triggered and result in spiritually connected individuals and have more intense emotions.

In general, psilocin acts on serotonin receptors. When this occurs, the serotonin levels in the brain increase, creating changes in perception; thus, this action by the psilocin plays a vital role in the various psychoactive effects of psilocybin mushrooms. 

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